Bupropion normalizes cognitive performance in patients with depression.

Abstract

Patients with mood disorders are known to have neurocognitive deficits in many, if not most, cognitive domains (1). In a recent paper, we showed that depressed patients on modern antidepressants had, in spite of successful treatment, residual deficits in tests of effortful attention, executive function and information processing speed (2). Although the cognitive impairments associated with depression are improved by effective antidepressant therapy, they do not tend to normalize (3,4,5,6).

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